CARDIOVASCULAR EFFECTS OF CYCLIC AMP AND DIBUTYRYL CYCLIC AMP, AND THEIR MODIFICATION BY METHYLXANTHINES

آدنوزین منوفسفات حلقوی ( Cyclic AMP )

Identification and cyclic AMP-induced modification of the cyclic AMP receptor in Dictyostelium discoideum.

We have recently identified a cell surface cAMP-binding protein by specific photoaffinity labeling of intact Dictyostelium discoideum cells with 8-N3-[32P] cAMP. The major photolabeled protein appears as a doublet (Mr = 40,000-43,000) in sodium dodecyl sulfate-polyacrylamide gel electrophoresis autoradiography. In this study, the doublet is shown to have the characteristics of the cAMP receptor...

The effect of cyclic AMP and dibutyryl cyclic AMP on the permeability characteristics of the renal tubule.

The effect of adenosine-3',5'-cyclic monophosphate (cyclic AMP) and N(6),O(2)-dibutyryl adenosine-3',5'-cyclic monophosphate (dibutyryl cyclic AMP) on renal tubular permeability was studied by microinjection techniques in anesthetized diuretic rats. Radioactive inulin and mannitol were microinjected simultaneously into superficial proximal and distal convolutions and recovery of the isotopes wa...

Human platelet secretion and aggregation induced by calcium ionophores. Inhibition by PGE1 and dibutyryl cyclic AMP

Ca2+, Mg2+-ionophores X537A and A23,187 (10(-7)-10(-6) M) induced the release of adenine nucleotides adenosine diphosphate (ADP, adenosine triphosphate (ATP), serotonin, beta-glucuronidase, Ca2+, and Mg2+ from washed human platelets. Enzymes present in the cytoplasm or mitochondria, and Zn2+ were not released. The rate of ATP and Ca2+ release measured by firefly lantern extract and murexide dye...

Human Platelet Secretion and Aggregation Induced by Calcium Ionophores Inhibition by PGE and Dibutyryl Cyclic AMP

Ca 2+, Mg2+-ionophores X537A and A23,187 (10-r-10 -6 M) induced the release of adenine nucleotides adenosine diphosphate (ADP, adenosine triphosphate (ATP), serotonin, /3-glucuronidase, Ca 2+, and Mg 2+ from washed human platelets. Enzymes present in the cytoplasm or mitochondria, and Zn 2+ were not released. The rate of ATP and Ca 2+ release measured by firefly lantern extract and murexide dye...